For de fleste vil den akutte fasen vare fra noen dager til noen uker i forbindelse med operasjon, skade eller sykdom. Hos noen kan smertene dessverre vare lenger. Bruk av sterke smertestillende medisiner har vist seg å ha liten effekt mot langvarige smerter. Et unntak er lindring av smerte ved kreftsykdom. Langvarig bruk av opioid kan gi keep bivi

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